He now considers everyone bandits, which he's intending to kill. Jack still has good intents, but utilizes it all wrong. Jack lost his mind from there, and still used the knowledge. Punching the relic was the cherry on the shake to complete the process. They betrayed him, making him lose trust. He started out as someone trying to save thousands of lives on Elpis, they took his pride. Also, they both are a main factor in Jack's insanity. They delibrately attempted to kill all of them, they would be casualities of war. In fact, Claptrap was Lilith and Roland's guide at the beginning of their adventure, and Athena returned a favor for saving her in Borderlands 1 by assisting in killing the Atlas commander each one of them was after. The Vault Hunters never did anything to Moxxi and Lilith. They were people he trusted, and they attempted to kill him AND the Vault Hunters. The guy was trying to eradicate most of the population of a planet and killing his own people if they so much as mentioned something he didn't like, way too late to be calling him a hero. i can pity the guy since we've seen more than enough from his past-life to show what created that darkness inside him, but Jack's too far-gone to be forgiven and just forget his errors. Handsome Jack became another tragic figure of Pandora where he let his own passions get the better of him and everything else got the backseat. While in Borderlands 2 Jack is right, we're not the heroes, we're kinda the anti-heroes really, but Jack goes from being Chaotic Neutral to Chaotic Evil in the game so he's still a bad guy through and through. Jack's a great character and easily one of the best bad guys in video games, mostly due to his wonderfully sadistic talks but also because we can actually see the human side still within him. I remember watching that Game Theory video and enjoying the new perspective on Jack but it still didn't change my opinion of him being the villain.